Toll-like receptor 2 or toll-like receptor 4 deficiency does not modify lupus in MRLlpr mice.

Toll-like receptor 2 or toll-like receptor 4 deficiency does not modify lupus in MRLlpr mice.

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Systemic lupus erythematosus is an autoimmune disease with a high morbidity and nephritis is a common manifestation.Previous studies in murine lupus models have suggest a role for Toll-like receptor 2 and 4.We examined the role of these molecules in MRL lpr mice which is one of the most animed blue lotion topical spray established and robust murine models.We compared disease parameters in Toll-like receptor 2 or Toll-like receptor 4 deficient mice with their littermate controls.

We found no difference in the severity of glomerulonephritis as assessed by histology, serum creatinine and albuminuria when Toll-like receptor 2 or Toll-like receptor 4 deficient MRLlpr mice were compared with Toll-like receptor sufficient controls.We also found similar levels click here of anti-dsDNA and anti-ssDNA antibodies.These results show that Toll-like receptor 2 and Toll-like receptor 4 do not play a significant role in MRLlpr mice, and therefore they may not be important in human lupus.